This book examined the Anglican Church’s history of mission in Central Nyanza, focusing on the formative role played by Reuben Omulo, a Luo mission innovator. It explores the key features of the mission praxis of Omulo and his encounters with the Church Missionary Society (CMS). The pre-colonial encounters forged the diverse Luo people into a nation, as this research clarified, and further described those complex relations, which shaped critical features of the Southern Luo world, priming them for their encounters with the European colonialist and the CMS missionaries.